4.6 Review

Exploring intermediate phenotypes with EEG: Working memory dysfunction in schizophrenia

期刊

BEHAVIOURAL BRAIN RESEARCH
卷 216, 期 2, 页码 481-495

出版社

ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2010.08.045

关键词

Working Memory; Encoding; Schizophrenia; EEG; Oscillations; Synchrony; Neuropharmacology

资金

  1. Wales Institute of Cognitive Neuroscience
  2. Welsh Assembly Government
  3. Medical Research Council [G0801418B] Funding Source: researchfish

向作者/读者索取更多资源

This review brings together two strands of investigation in the neuropsychology and neurophysiology of schizophrenia that have been particularly productive over the last 20 years. We review the literature on working memory deficits, particularly in the visual domain, and changes in oscillatory neural activity as measured with electroencephalography (EEG) and magnetoencephalography (MEG). We argue that recent results suggest a link between these two phenomena, in that altered oscillations underlie some of the working memory deficits. We furthermore argue that early sensory mechanisms contribute more to working memory (and other) deficits than previously thought. The final part of our review suggests links between working memory, oscillations, and their alterations in schizophrenia and the dopamine, GABA, glutamate and acetylcholine system. These links have already resulted in the development of new remediation strategies, which have some translational potential. (C) 2010 Elsevier B.V. All rights reserved.

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