期刊
BEHAVIOURAL BRAIN RESEARCH
卷 225, 期 1, 页码 382-387出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2011.07.033
关键词
Immune; Context; Memory; Reversal; Schizophrenia; Rat
资金
- Health Research Council of New Zealand
Schizophrenia is associated with changes in memory and contextual processing. As maternal infection is a risk factor in schizophrenia we tested for these impairments in a maternal immune activation (MIA) animal model. MIA rats displayed impaired object recognition memory, despite intact object discrimination, and a reduced reinstatement of rearing in response to a contextual manipulation. These results link MIA to contextual impairments in schizophrenia, possibly through changes in hippocampal function. (C) 2011 Elsevier B.V. All rights reserved.
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