期刊
BEHAVIOURAL BRAIN RESEARCH
卷 216, 期 1, 页码 463-465出版社
ELSEVIER
DOI: 10.1016/j.bbr.2010.07.034
关键词
Lateral habenula; Depression; Learned helplessness; Treatment resistance; LHb; cLH
Identifying new treatment approaches for treatment resistant depression (TRD) is an important topic for translational psychiatry. Functional inhibition of the lateral habenula (LHb) has recently been claimed to offer such an option for TRD. Rats which are bred for high susceptibility to develop learned helplessness provide a genetic model for TRD. We used the gamma-aminobutyric acid agonist muscimol to inhibit the LHb in Sprague-Dawley rats with congenital learned helplessness (cLH). Stereotactic pharmacological inhibition of the LHb exerted antidepressive effects in treatment resistant cLH rats. (C) 2010 Elsevier B.V. All rights reserved.
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