期刊
BEHAVIOURAL BRAIN RESEARCH
卷 225, 期 1, 页码 77-84出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2011.06.035
关键词
Basolateral amygdala; p-ERK1/2; Stress; Contextual fear memory; Memory consolidation
资金
- MinCyT-Cordoba
- SECYT-UNC
- CONICET
- Agencia Nacional de Promocion Cientifica y Tecnologica - FONCYT (Argentina)
It is well known that an emotionally arousing experience usually results in a robust and persistent memory trace. The present study explored the potential mechanisms involved in the influence of stress on the consolidation of a contextual fear memory in animals subjected to a weak fear training protocol, and whether pretreatment with intra-basolateral amygdala or systemic administration of midazolam (MDZ) prevents the potential stress-induced influence on fear memory formation. A previous restraint session facilitated fear retention, this effect was not due to a sensitized effect of restraint on the footshock experience. MDZ, both systemically or intra-basolateral amygdala infusion prior to the restraint, attenuated the stress-induced promoting influence on fear memory formation. In addition, stress exposure activated the ERK1/2 pathway in basolateral amygdala (BLA) after the weak training procedure but not after the immediate footshock protocol. Similar to our behavioral findings, MDZ attenuated stress-induced elevation of phospho-ERK2 (p-ERK2) in BLA following the acquisition session. Given that the activation of ERK1/2 pathway is essential for associative learning, we propose that stress-induced facilitation of p-ERK2 in BLA is an important mechanism for the promoting influence of stress on the consolidation of contextual fear memory. (C) 2011 Elsevier B.V. All rights reserved.
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