期刊
JOURNAL OF VIROLOGY
卷 75, 期 17, 页码 8195-8202出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.75.17.8195-8202.2001
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资金
- NCRR NIH HHS [M01-RR00042, M01 RR000042] Funding Source: Medline
- NHLBI NIH HHS [HL57885] Funding Source: Medline
- NIAID NIH HHS [AI07528, T32 AI007528, AI36685] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007315, T32 GM007863, T32 GM07863, GM07315] Funding Source: Medline
Production of the C-X-C chemokines interleukin-8 (IL-8) and growth-regulated oncogene alpha (GRO-alpha) in macrophages is stimulated by exposure to human immunodeficiency virus type 1 (HIV-1). We have demonstrated previously that GRO-a then stimulates HIV-1 replication in both T lymphocytes and macrophages. Here we demonstrate that IL-8 also stimulates HIV-1 replication in macrophages and T lymphocytes. We further show that increased levels of IL-8 are present in the lymphoid tissue of patients with AIDS. In addition, we demonstrate that compounds which inhibit the actions of IL-8 and GRO-a via their receptors, CXCR1 and CXCR2, also inhibit HIV-1 replication in both T lymphocytes and macrophages, indicating potential therapeutic uses for these compounds in HIV-1 infection and AIDS.
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