Opposing roles for dopamine D1- and D2-like receptors in discrete cue-induced reinstatement of food seeking

We used a rat reinstatement model to test the involvement of dopamine D-1- and D-2-like receptors in discrete cue-induced reinstatement of food seeking. At a dose that did not alter responding during food self-administration, the D-1-like antagonist SCH-23390 blocked reinstatement of food seeking, while the D-2-like antagonist eticlopride significantly increased reinstatement responding. Thus, these results establish opposing roles for D-1- and D-2-like receptors in discrete cue-induced relapse to food seeking. (C) 2011 Elsevier B.V. All rights reserved.