期刊
BEHAVIOURAL BRAIN RESEARCH
卷 222, 期 2, 页码 357-362出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2011.03.066
关键词
Rat; Startle amplitude; Freezing; Contextual conditioning; Bed nucleus of the stria terminalis; Lesion; Anxiety
资金
- Research Foundation - Flanders (FWO) [G.0729.09N]
Expression of contextual anxiety in a previously shocked context is a widely used model of anxiety, with the main behavioral measures being freezing or startle amplitude. There is extensive evidence that the bed nucleus of the stria terminalis (BST) is involved in several anxiety paradigms, e.g. BST lesions disrupt contextual freezing. Surprisingly, studies investigating the effect on startle potentiation in a conditioned context are still lacking in the literature. In the present study, we found that post-training bilateral electrolytic lesions in the BST completely disrupted the expression of contextual anxiety, as quantified with combined measurements of startle amplitude and freezing. (C) 2011 Elsevier B.V. All rights reserved.
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