期刊
BEHAVIOURAL BRAIN RESEARCH
卷 215, 期 2, 页码 318-325出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2009.09.014
关键词
Recognition; Temporal order; Spatial memory; Object memory; Lesions; Mice
资金
- Conte Center for Schizophrenia Research (NIH) [NIH MH60450]
There is a current controversy regarding whether non-human animals have a capacity for episodic memory, defined by the ability to remember what happened and where and when it occurred. It is also unclear which brain structures support the what, where, and when aspects of episodic memory. Here we addressed these issues by testing episodic memory in mice, using an object recognition task that has previously been employed to assess the what, where, and when components of recognition memory. Whereas intact mice remembered which objects they had explored, as well as when and where they were experienced, mice with damage to the hippocampus were impaired on all three components of the task. In contrast, animals with medial prefrontal cortical lesions were selectively impaired on the where component of the task, but had intact memory for what and when. These results are consistent with the hypothesis that the hippocampus integrates the what, where, and when features of unique experiences, whereas the prefrontal cortex makes a more selective contribution to retrieving source information about where events occurred. (C) 2009 Elsevier B.V. All rights reserved.
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