期刊
BEHAVIOURAL BRAIN RESEARCH
卷 210, 期 2, 页码 211-220出版社
ELSEVIER
DOI: 10.1016/j.bbr.2010.02.033
关键词
Social recognition; Anxiety; Aggressiveness; Estrogen receptor alpha; Medial posterodorsal amygdala; Ventromedial nucleus of the hypothalamus
资金
- University of Tromso
- [MH 38273]
- [HD 05751]
Social recognition manifests itself in decreased investigation of a previously encountered individual. Estrogen receptor alpha (ER alpha) knock out mice show deficient social recognition and anxiety. These data show that the ER alpha is involved in these effects, but they do not say anything about the brain sites important for these effects. In this study, an shRNA encoded within an AAV viral vector directed against the ER alpha receptor gene (or containing luciferase control), was injected bilaterally into the posterodorsal amygdala (MePDA) or the ventromedial nucleus of the hypothalamus (VMN) of female rats. An 81% reduction of ER alpha expression in the MePDA eliminated social recognition. Moreover, this diminution of ER alpha in the MePDA reduced anxiety in the light/dark choice test. In contrast, social recognition was unaffected after ERa knockdown in the VMN while aggressiveness against the juvenile was enhanced. In conclusion, social recognition and anxiety in female rats are modulated by the ER alpha in the amygdala. Moreover, aggression against juveniles but not against adults could, at least partly, depend on the ER alpha in the VMN. (C) 2010 Elsevier B.V. All rights reserved.
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