期刊
BEHAVIOURAL BRAIN RESEARCH
卷 208, 期 1, 页码 231-236出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2009.11.043
关键词
Attention deficit hyperactivity disorder (ADHD); Drug abuse; Environment enrichment; Conditioned place preference (CPP); Ethanol self-administration; Spontaneously hypertensive rat (SHR)
资金
- Conselho Nacional cle Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil
- Coordenacao cle Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Brazil
- Programa de Apoio aos Nucleos de Exclencia (PRONEX), Brazil
- Fundacao de Apoio a Pesquisa do Estado de Santa Catarina (FAPESC), Brazil
The present study investigated the consequences of environmental enrichment on the impact of novelty and motivational properties of ethanol in spontaneously hypertensive rats (SHR), a validated model of attention deficit hyperactivity disorder (ADHD). This rat strain displays increased sensitivity to distinct classes of abused drugs, which makes it an interesting model for the study of the association between ADHD and drug abuse. Female SHR reared from weaning to adulthood in standard (SE) or enriched (EE) environment were tested on novelty-induced locomotion, saccharin consumption, ethanol consumption (forced and free-choice schedules) and ethanol-induced conditioned place preference (CPP). SHR reared in an EE showed reduced novelty-induced locomotion, consumed less saccharin and ethanol in a forced schedule and showed less ethanol preference in a free-choice schedule compared to SE rats. Moreover, EE rats did not develop CPP, whereas SE rats developed preference for ethanol (1.2 g/kg). These results show that exposure to stimuli mimicking positive life experiences (environmental enrichment) induces persistent changes in the reward/motivational system of female SHR, suggesting an important role of the familiar environment during early stages of the neurodevelopment on the co-morbidity of ADHD and drug abuse. (C) 2009 Elsevier B.V. All rights reserved
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据