期刊
BEHAVIOURAL BRAIN RESEARCH
卷 209, 期 2, 页码 212-220出版社
ELSEVIER
DOI: 10.1016/j.bbr.2010.01.045
关键词
Mucopolysaccharidosis; Sanfilippo; Lysosomal storage disease; Circadian rhythm; Behaviour; Synaptic loss; Neurodegenerative disease; MPSIIIB; Suprachiasmatic nucleus
资金
- UK Society for Mucopolysaccharide Diseases
- Research Councils UK
- Biotechnology and Biological Sciences Research Council
- NIHR Manchester Biomedical Research Centre
- Lady Shauna Gosling Trust
Mucopolysaccharidosis IIIB (MPSIIIB) is a lysosomal storage disease characterised by progressive central nervous system degeneration in patients, with death usually in the late teens. Serious behavioural problems have been reported in children at the early stages of the disease, such as hyperactivity and severe sleep disturbances, which suggest alterations in circadian rhythms. We investigated the circadian rhythm of locomotor activity of young and old MPSIIIB mice, under a 24-h light-dark (LD) cycle and under constant darkness (DD), and also examined neuropeptide expression in the suprachiasmatic nucleus (SCN), site of the principal biological pacemaker. We show that MPSIIIB mice have higher activity levels during the light (resting) phase of the LD cycle, together with weaker circadian rhythms, and a longer active phase due to a late peak of activity, in both LD and DD. In addition, young MPSIIIB mice showed shorter phase delays in response to a light pulse in DD. Increased lysosomal storage, neuroinflammation and changes in the expression of Arginine Vasopressin and Vasointestinal Polypeptide, two circadian neuropeptides, were observed in the SCN, which may be in part responsible for the changes in circadian behaviour observed in MPSIIIB mice. These findings suggest an alteration of the circadian system in MPSIIIB mice, and may inform better clinical management of circadian, sleep and behavioural disturbances in patients with MPSIII. (C) 2010 Elsevier B.V. All rights reserved.
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