期刊
BEHAVIOURAL BRAIN RESEARCH
卷 208, 期 2, 页码 371-376出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2009.12.004
关键词
Zebrafish; Stress; Anxiety; Withdrawal; Novel tank test; Cortisol
资金
- Georgetown University's Stress Physiology and Research Center
- University of New Orleans
- Tulane University
- Gordon and the G. Lurcy Fellowships
- Provost's Scholarly Enrichment Fund
- Newcomb Fellows Grant
- NARSAD
The zebrafish (Danio rerio) is rapidly becoming a popular model species in behavioral neuroscience research. Zebrafish behavior is robustly affected by environmental and pharmacological manipulations, and can be examined using exploration-based paradigms, paralleled by analysis of endocrine (cortisol) stress responses. Discontinuation of various psychotropic drugs evokes withdrawal in both humans and rodents, characterized by increased anxiety. Sensitivity of zebrafish to drugs of abuse has been recently reported in the literature. Here we examine the effects of ethanol, diazepam, morphine and caffeine withdrawal on zebrafish behavior. Overall, discontinuation of ethanol, diazepam and morphine produced anxiogenic-like behavioral or endocrine responses, demonstrating the utility of zebrafish in translational research of withdrawal syndrome. (C) 2009 Elsevier B.V. All rights reserved.
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