期刊
BEHAVIOURAL BRAIN RESEARCH
卷 201, 期 2, 页码 239-243出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2009.03.004
关键词
Depression; Ventromedial prefrontal cortex; Dorsolateral prefrontal cortex
资金
- National Institute of Neurological Disorders and Stroke intramural research program [DAMD17-01-1-0675]
A primary aim in the neuroscientific study of depression is to identify the brain areas involved in the pathogenesis of symptoms. In this review, we describe evidence from studies employing various experimental approaches in humans (functional imaging, lesion method, and brain stimulation) that converge to implicate the ventromedial and dorsolateral sectors of prefrontal cortex as critical neural substrates for depression, albeit with distinct functional contributions. The putative roles of ventromedial and dorsolateral prefrontal cortex in depression are discussed in light of the results. (C) 2009 Elsevier B.V. All rights reserved.
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