期刊
BEHAVIOURAL BRAIN RESEARCH
卷 198, 期 2, 页码 366-371出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2008.11.016
关键词
Antidepressant; IGF-I; Behavior; Mouse; Exercise; Forced-swim test; Novelty-induced hypophagia
资金
- USPHS [MH45481, 21301 MH25642]
- Veterans Administration National Center
- Connecticut Mental Health Center
Growth factors in the brain are important to depression and it's treatment and we assessed the ability of peripherally administered insulin-like growth factor-I (IGF-I) to influence behavior related to depression. We found that mice that received chronic IGF-I treatment showed antidepressant-like behavior in forced-swim and novelty-induced hypophagia (NIH) tests and increased sucrose consumption after chronic mild unpredictable stress exposure. Additionally, peripheral anti-IGF-I administration blocked exercise-induced antidepressant effects in the forced-swim test (FST). These results support the functional relevance of neurotrophic mechanisms to depression and extend this idea to include neurotrophic factors in the periphery. (C) 2008 Elsevier B.V. All rights reserved.
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