期刊
BEHAVIOURAL BRAIN RESEARCH
卷 197, 期 2, 页码 398-403出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2008.10.010
关键词
Cognition; Parkinson's disease; Dementia; Pioglitazone; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Oxidative stress; Substantia nigra pars compacta
资金
- DST [VII-PRDSF/85/05-06/TDT]
- Department of Pharmaceuticals
- Ministry of Chemicals & Fertilizers, Govt. of India
The present study was carried out to elucidate the beneficial effect of pioglitazone in cognitive impairment induced by bilateral infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in substantia nigra pars compacta (SNc) in rats, a model of Parkinson's disease. MPTP-lesioned rats showed poor cognitive performance in both passive avoidance task and cued version of the Morris water maze test. This deficit in learning and memory was found to be associated with oxidative stress. Chronic administration of pioglitazone (10 and 30 mg/kg, p.o., starting 5 days prior to MPTP administration and then for next 30 days) in MPTP-lesioned rats improved cognitive performance in passive avoidance task and cued version of the Morris water maze test. Furthermore, pioglitazone treatment also reduced oxidative stress (as evident by reduced malondialdehyde and increased glutathione levels). These results demonstrate the beneficial effects of pioglitazone on cognitive impairment in MPTP induced Parkinson's disease in rats. (C) 2008 Elsevier B.V. All rights reserved.
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