期刊
BEHAVIOURAL BRAIN RESEARCH
卷 197, 期 1, 页码 119-124出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2008.08.009
关键词
Nucleus accumbens; CB1 receptor; Morphine; Conditioned place preference; Sensitization; Rat
资金
- Neuroscience Research Center, Shahid Beheshti University, M.C., Tehran, Iran [86-436-A]
It has been shown that cannabinoids interact with the opiate system in reward-related behaviors and in animal models of addiction. In the present study, the effects of bilateral intra-accumbal administration of AM251, a CB1 receptor antagonist, on the acquisition and expression of ineffective dose of morphine-induced conditioned place preference (CPP) in morphine-sensitized rats were investigated. 158 adult male albino Wistar rats were used in these experiments. Subcutaneous (s.c.) administration of morphine (0.25, 0.5, 0.75, 1, 2.5 and 5 mg/kg) induced CPP only at the dose of 5 mg/kg. In addition, repeated administration of morphine (5 mg/kg; s.c.), once daily for 3 days followed by 5 days free of the opioid (sensitization period), increased conditioning response induced by ineffective doses of morphine (0.25, 0.5 and 0.75 mg/kg). Bilateral intra-accumbal administration of AM251 (5, 25 and 125 ng/0.5 mu l per side) dose-dependently reduced the acquisition and expression of morphine-induced CPP in morphine-sensitized rats, while bilateral intra-accumbal administration of neither saline nor DMSO (05 mu l/side) had effects on the acquisition and expression of morphine-induced CPP in sensitized rats. The results indicated that CBI receptors within the nucleus accumbens are involved in the acquisition and expression of morphine-induced CPP in sensitized rats. Our findings also suggest the existence of cross-talk between cannabinoids and opiates on the sensitization to morphine and the implication of endocannabinoid system in the process of sensitization to opiates. (C) 2008 Elsevier B.V. All rights reserved.
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