期刊
JOURNAL OF PEPTIDE SCIENCE
卷 7, 期 9, 页码 502-510出版社
WILEY-BLACKWELL
DOI: 10.1002/psc.345
关键词
histidine; im-Bum protection; racemization; SPPS
This paper presents a reevaluation of the synthesis and properties of Fmoc-His(3-Bum)-OH regarding its application in SPPS with minimal racemization of histidine residues during coupling and esterification reactions. By-product formation during the deprotection of the test peptides could be significantly reduced by scavenging the concomitantly formed HCHO, e.g. with methoxyamine. Copyright (C) 2001 European Peptide Society and John Wiley & Sons. Ltd.
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