期刊
BEHAVIOURAL BRAIN RESEARCH
卷 196, 期 2, 页码 261-267出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2008.09.017
关键词
Androstenedione; Lordosis; Feminization; Masculinization; Sex differences; Androgens; Sexual behavior; Accessory olfactory bulb; Lateral septum; Ventromedial nucleus of the hypothalamus; Lordosis inhibition
资金
- MCYT [SEJ2007-65686, SEJ2007-62942]
Male rats, under certain experimental conditions, may show lordosis, the typical expression of female sexual receptivity. This work studies the sexual morphological pattern of facilitatory and inhibitory structures that control lordosis. Three groups of males were neonatally subjected to a gradient of androgen exposure (castrated plus injected oil (GxM + oil); castrated plus androstenedione treated (GxM + AND); and sham operated [CM]); a group of control females (CF) was also added. Lordotic response after these different hormonal and neonatal Surgical treatments, as well as the volume or number of neurons in facilitatory (ventromedial nucleus of the hypothalamus [VMN 1) and inhibitory (the intermediate region of the lateral septum [LSi] and accessory olfactory bulb [AOB]) nuclei involved in lordosis was studied in adults. The inhibition of lordosis in the males seems to be associated to the neonatal presence of testosterone and the consequent masculinization of the VMN, VMNvl, LSi and AOB. It is suggested that one of the functions of the sex differences consistently seen in these structures might be to inhibit the lordosis response in the male. (C) 2008 Elsevier B.V. All rights reserved.
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