期刊
BEHAVIOURAL BRAIN RESEARCH
卷 201, 期 2, 页码 338-342出版社
ELSEVIER
DOI: 10.1016/j.bbr.2009.03.001
关键词
Stress; Frontal cortex; Elevated T-maze; Anxiety; Restraint; Rodent
资金
- MEC [SEJ2007-61187, CTS-195]
- FPU-MEC [AP-2006-02582]
The medial prefrontal cortex has been associated with fear, anxiety and stress regulation, and has recently been suggested to play a crucial role in the development of behavioural changes in response to stress. In this study, we evaluated medial prefrontal cortex (mPFC) involvement in both anxiety-like behaviour and increased anxiety-like responses induced by uncontrollable restraint. Rats with mPFC electrolytic lesions (n = 7) and sham-lesioned (n = 8) were tested in the elevated T-maze (ETM). Restrained rats with mPFC lesions (n = 8) and sham-lesioned rats (n = 6) were tested in the elevated T-maze 24 h after restraint. Both two-trial passive avoidance and one-trial escape behaviours; were assessed. The results revealed that mPFC lesions impair passive avoidance, but not escape behaviour. in addition, decreased anxiety-like behaviour in both passive avoidance and escape behaviours were observed in restrained rats with mPFC lesions. Our results suggest that mPFC is important in mediating both anxiety-like behaviour expression and long-term anxiogenic-like effects induced by acute restraint. (C) 2009 Elsevier B.V. All rights reserved.
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