期刊
BEHAVIOURAL BRAIN RESEARCH
卷 193, 期 2, 页码 315-319出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2008.06.016
关键词
Sandhoff disease; mouse model; novel object recognition test; rotarod; motor coordination; balance beam; open field; memory
资金
- the Lysosomal Storage Disease Research Consortium
Mouse models of lysosomal storage diseases, including Sandhoff disease, are frequently employed to test therapies directed at the central nervous system. We backbred such mice and conducted a behavioral test battery which included sensorimotor and cognitive assessments. This is the first report of short-term memory deficits in a murine model of Sandhoff disease. We also document early onset of motor deficits using the balance beam test. (C) 2008 Elsevier B.V. All rights reserved.
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