期刊
BEHAVIOURAL BRAIN RESEARCH
卷 193, 期 1, 页码 140-143出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2008.04.021
关键词
animal model; BALB/c; depression; desipramine; fluoxetine; imipramine; maprotiline; Swiss
There have been few comparisons of strains and antidepressants in the unpredictable chronic mild stress (UCMS) paradigm in mice. This study was undertaken to determine the influence of such factors using four antidepressants drugs including the tricyclics imipramine (20 mg/(kg day)) and desipramine (10 mg/(kg day)), the tetracyclic maprotiline (20 mg/(kg day)) and the selective serotonin reuptake inhibitor (SSRI) fluoxetine (10 mg/(kg day)) in both Swiss and BALB/c mice. A 6-week UCMS regimen induced deterioration of the coat state and decreased grooming behaviours in the splash test in BALB/c mice but not Swiss mice. The four antidepressants reversed the UCMS-induced effects in BALB/c mice in both measures. However, imipramine and fluoxetine reached significance in the splash test while desipramine and maprotiline displayed only a trend. In conclusion, these results emphasize that BALB/c mice are more sensitive than Swiss mice for studying the effects of the UCMS model as well as for testing antidepressant-like Properties. (C) 2008 Elsevier B.V. All Fights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据