期刊
BEHAVIOURAL BRAIN RESEARCH
卷 189, 期 2, 页码 244-249出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2007.12.031
关键词
ADHD; schizophrenia; disease model; anxiety; impulsivity; novelty seeking
资金
- NIMH NIH HHS [P50 MH068789, P50 MH 068789, P50 MH068789-020002, P50 MH068789-010002] Funding Source: Medline
- NINDS NIH HHS [T32 NS045543, T32 NS 045543] Funding Source: Medline
Gene linkage and association studies have implicated the region of chromosome 10q containing the calcyon locus with attention deficit hyperactivity disorder (ADHD), bipolar disorder, and schizophrenia susceptibility. In addition, levels of calcyon protein and transcripts are also significantly increased in postmortem tissue from schizophrenic brains. But whether altered calcyon expression might be part of the disease etiology or merely a patho-physiological side effect is not known. To begin to address this issue, we generated a transgenic mouse line (Cal(OE)) using the human calcyon cDNA in which calcyon expression is up-regulated in a number of forebrain structures including the hippocampus, prefrontal cortex (PFC), striatum, and amygdala. Compared to control littermates, the Cal(OE) mice display a range of abnormal behaviors including spontaneous hyperactivity, reduced anxiety, and/or impaired restraint (harm avoidance) that would indicate that calcyon up-regulation leads to deficits in control over behavioral output. (C) 2008 Elsevier B.V. All rights reserved.
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