期刊
BEHAVIOURAL BRAIN RESEARCH
卷 195, 期 1, 页码 120-128出版社
ELSEVIER
DOI: 10.1016/j.bbr.2007.11.029
关键词
Memory; Serotonin; CaMKII; MAPK
资金
- Conselho Nacional de Desen-volvimento Cientifico e Tecnologico do Brasil (CNPq)
- Consejo Nacional de Investigaciones Cientificas y Tecnicas de Argentina (CONICET)
Activity-dependent changes in neuronal efficacy underlie the formation and storage of new memories. Several studies indicate that modification of the phosphorylation/activation state of different protein kinases localized in the synapses or the nucleus plays a critical role in the induction and maintenance of plastic mechanisms and in the consolidation of long-lasting memories. Here we review some of the more recent findings concerning the regulation of two of the main protein kinase groups involved in memory processes and in neuronal plasticity: Ca2+/calmodulin-dependent protein kinase II (CaMKII), and the mitogen-activated protein kinase (MAPK) family. Since this issue of the journal is dedicated to serotonin (5HT) regulation of behavior, we will comment on the so far scanty, but significant, evidence for a role of 5HT in the regulation of CaMKII and MAPK. (C) 2008 Elsevier B.V. All rights reserved.
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