期刊
JOURNAL OF AFFECTIVE DISORDERS
卷 66, 期 1, 页码 89-93出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0165-0327(00)00321-9
关键词
major depression; melancholia; S-100B; neurodegeneration
Background: Recent evidence suggests that neuro degeneration may be involved in the pathophysiology of major depression. The astroglial peptide S-100B was shown to be increased in many diseases causing neuronal cell damage or degeneration. Method: S-100B plasma levels were determined in 28 patients with major depression and 28 matched healthy controls using an immunofluorometric sandwich assay. Results: Patients suffering from melancholic depression showed significantly increased S-100B levels compared to healthy controls while non-melancholic patients demonstrated normal levels. Limitations: Medication of patients varied. The differentiation between melancholic and non-melancholic patients was performed clinically without using a standardized instrument. Conclusions: Neurodegeneration or axonal remodeling may be involved in the pathogenesis of melancholic depression. (C) 2001 Elsevier Science BY All rights reserved.
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