期刊
NATURE CELL BIOLOGY
卷 3, 期 9, 页码 809-815出版社
MACMILLAN PUBLISHERS LTD
DOI: 10.1038/ncb0901-809
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- NIAID NIH HHS [AI31078] Funding Source: Medline
- NIGMS NIH HHS [GM61110] Funding Source: Medline
The precise regulation of growth factor signalling is crucial to the molecular control of development in Drosophila. Post-translational modification of signalling molecules is one of the mechanisms that modulate developmental signalling specificity. We describe a new gene, fringe connection (frc), that encodes a nucleotide-sugar transporter that transfers UDP-glucuronic acid, UDP-N-acetylglucosamine and possibly UDP-xylose from the cytoplasm into the lumen of the endoplasmic reticulum/Golgi. Embryos with the frc mutation display defects in Wingless, Hedgehog and fibroblast growth factor signalling. Clonal analysis shows that fringe-dependent Notch signalling is disrupted in frc mutant tissue.
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