期刊
BEHAVIORAL NEUROSCIENCE
卷 126, 期 5, 页码 681-689出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/a0029534
关键词
Pavlovian instrumental transfer; cocaine; self-administration; seeking taking chain; addiction
资金
- National Institute on Drug Abuse [DA09359, DA05010, DA029035]
- [T32-DA024635]
Drug-associated cues are believed to be important mediators of addiction and drug relapse. Although such cues may influence drug-seeking behavior through multiple routes, it is their putative incentive motivational properties-their ability to elicit craving-that interests many addiction researchers. The Pavlovian-to-instrumental transfer paradigm is commonly used to assay cue-evoked incentive motivation in situations involving natural rewards, but has not been widely applied to the study of drug self-administration. We used this paradigm to determine whether cues paired with intravenous cocaine could promote performance of an independently trained task in which rats self-administered cocaine by completing a chain of two different lever press actions, a procedure used to parse behavior into cocaine seeking (first action) and cocaine taking (second action). Rats showed significant transfer, increasing task performance during cocaine-paired cues. This effect was observed for both seeking and taking actions, although a trend toward greater cocaine taking was observed, a result that is consistent with studies using natural rewards. Our results demonstrate that cocaine-paired cues can provoke the pursuit of cocaine through a Pavlovian motivational process. This phenomenon may provide a useful new tool for modeling drug relapse, particularly as a method for targeting the response-invigorating effects of stimulus-drug learning.
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