期刊
BEHAVIORAL NEUROSCIENCE
卷 126, 期 2, 页码 361-369出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/a0027161
关键词
essential fatty acid deficiency; maternal diet; docosahexaenoic acid; anxiety; elevated plus maze; light-dark transition
资金
- Swedish Research Council [K2009-65X-15424-05-3]
- Swedish Federal Government under the LUA/ALF
- Foundations of the National Board of Health and Welfare
- Torsten and Ragnar Soderberg Foundation
- Clas Groschinsky Foundation
- Arosenius Foundation
- Ake Wiberg Foundation
- Jeansson Foundation
- Tore Nilsson Foundation for Medical Research
- Magnus Bergvall Foundation
- Swedish Society for Medical Research
- Wilhelm and Martina Lundgren Science Foundation
Dietary essential fatty acids have been shown to regulate behavioral and cognitive functions in rodents. However, the long-term effect on behavior, besides memory and learning, of essential fatty acid deficiency (EFAD), i.e., lack of n-3 and n-6 fatty acids, during the perinatal period has not been investigated. Therefore, pregnant C57B1/6 mice were given either an EFAD or an isoenergetic control diet from gestational day 16 and throughout lactation. The female offspring were given standard chow from 3 weeks of age, and at 12 to 14 weeks of age, open-field, object recognition, light-dark transition, elevated plus maze, and social interaction tests were performed. The brain glycerophospholipid fatty acid composition was investigated in 3-week-old and adult offspring by gas chromatography. The differences observed in behavior were indicative of lower anxiety in the EFAD mice compared to controls illustrated by more time spent in the open arms of the elevated plus maze (+ 41%, p < .05) and in the light compartment in the light-dark transition test (+ 63%, p < .05). The proportion of total n-3 fatty acids, especially 22:6n-3 in the brain, was lower with a compensatory increase in the proportion of total n-6 fatty acids, foremost 22:5n-6, in the EFAD mice compared to controls at 3 weeks of age. In the adult brains the fatty acid composition was normalized. In conclusion, our data show that EFAD during the perinatal period results in short-term alterations of fatty acid composition in brain and decreased anxiety in adult life.
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