期刊
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
卷 78, 期 3, 页码 291-298出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-0760(01)00093-0
关键词
licorice root; glabridin; estrogen receptor
Licorice root extract and its major isoflavan, glabridin, exhibited varying degrees of estrogen receptor (ER) agonism in different tissues in vitro and in vivo. Animals fed with licorice extract, compared with estradiol and glabridin, showed an increase in creatine kinase (CK) activity, a known marker for estrogen responsive genes, which was higher than expected from the levels of glabridin in the extract. This led us to test for other components that may contribute to this strong estrogen agonist activity. Results indicated that glabrene and isoliquiritigenin, (2 ' ,4 ' ,4-three hydroxy chalcone) (ILC) in the licorice extract can bind to the human ER with higher affinity (IC50, 1 and 0.5 muM) than glabridin (IC50, 5 muM). The stimulatory effects of glabrene in vivo were tissue specific and similar to those of estradiol, The effect of increasing concentrations of glabrene and ILC on the growth of breast tumor cell were biphasic. Both showed an ER-dependent growth-promoting effect at low concentrations (10 nM-10 muM), and ER-independent antiproliferative activity at concentrations > 15 muM. This is the first study to indicate that glabrene, an isoflavene exerted varying degrees of ER agonism in different tissues. (C) 2001 Elsevier Science Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据