期刊
BEHAVIORAL NEUROSCIENCE
卷 124, 期 4, 页码 446-454出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/a0020081
关键词
dentate gyrus; memory; learning; hippocampus; postnatal neurogenesis; contextual fear conditioning
资金
- Ruth L. Kirschstein Research Service [F31MH084529]
- National Alliance for Research on Schizophrenia and Depression (NARSAD)
- New York Stem Cell Initiative
- National Institutes of Health [R01 MH068542]
- National Institute of Mental Health [K99 MH083943]
- Charles H. Revson Foundation
The role of adult hippocampal neurogenesis in contextual fear conditioning (CFC) is debated. Several studies demonstrated that blocking adult hippocampal neurogenesis in rodents impairs CFC, while several other studies failed to observe an impairment. We sought to determine whether different CFC methods vary in their sensitivity to the arrest of adult neurogenesis. Adult neurogenesis was arrested in mice using low-dose, targeted x-irradiation, and the effects of irradiation were assayed in conditioning procedures that varied in the use of a discrete conditioned stimulus, the number of trials administered, and the final level of conditioning produced. We demonstrate that irradiation impairs CFC in mice when a single-trial CFC procedure is used but not when multiple-trial procedures are used, regardless of the final level of contextual fear produced. In addition, we show that the irradiation-induced deficit in single-trial CFC can be rescued by providing preexposure to the conditioning context. These results indicate that adult hippocampal neurogenesis is required for CFC in mice only when brief training is provided.
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