期刊
BEHAVIORAL NEUROSCIENCE
卷 123, 期 3, 页码 665-676出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/a0015662
关键词
cerebellum; mental retardation; aging; longitudinal; FMRP
资金
- National Institutes of Health [AG09752, AG21025, AG23742]
- NATIONAL INSTITUTE ON AGING [R01AG023742, R01AG009752, R01AG021925] Funding Source: NIH RePORTER
The authors examined 400 ins delay eyeblink classical conditioning in 20 participants with Fragile X syndrome ages 17 to 77 years, and 20 age-matched, healthy control participants. The participants in the Fragile X group demonstrated impaired learning and abnormal conditioned response timing. Adults with Fragile X (n = 16) were also tested at two successive 12-month follow-up sessions to examine reacquisition and long-term retention. Participants in groups who were older and younger than 45 years demonstrated significant learning during each reacquisition session. Younger participants demonstrated greater retention of the conditioned stimulus/unconditioned stimulus association at each follow-up session than older participants. Fragile X impairs the acquisition and timing of conditioned eyeblink responses. but with repeated training adults with Fragile X syndrome show significant plasticity.
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