期刊
BEHAVIORAL NEUROSCIENCE
卷 122, 期 1, 页码 54-62出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.122.1.54
关键词
aging; discrimination; reversal learning; olfactory; visual object
资金
- NIA NIH HHS [AG026505, R01 AG026505, R01 AG026505-03] Funding Source: Medline
- NIGMS NIH HHS [T34 GM008303, 5T34GM08303] Funding Source: Medline
The present study investigated age-related differences in discrimination and reversal learning for olfactory and visual stimuli in 6-month and 24-month-old rats. Rats were trained to discriminate between two pseudo-randomly selected odors or objects. Once each animal reached a criterion on discrimination trials, the reward contingencies were reversed. Young and aged rats acquired the olfactory and visual discrimination tasks at similar rates. However, on reversal trials, aged rats required significantly more trials to reach the learning criterion on both the olfactory and visual reversal tasks than young rats. The deficit in reversal learning was comparable for odors and objects. Furthermore, the results showed that rats acquired the olfactory task more readily than the visual task. The present study represents the first examination of age-related differences in reversal learning using the same paradigm for odors and objects to facilitate cross-modal comparisons. The results may have important implications for the selection of memory paradigms for future research studies on aging.
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