期刊
BEHAVIORAL NEUROSCIENCE
卷 122, 期 2, 页码 368-376出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.122.2.368
关键词
maternal memory; NA shell; dopamine D-1 receptor; dopamine D-2 receptor
Female rats show enhanced maternal responsiveness toward their young if they have had maternal experiences before. This kind of maternal experience-based memory is critically dependent on the mesolimbic dopamine (DA) system, especially the nucleus accumbens (NA) shell. However, the relative contributions of the two main DA receptor systems (D-1 and D-2) within the shell have not been delineated. This study investigates the roles of dopamine D-1 and D-2 receptors in maternal memory by infusing a selective D-1 antagonist, SCH-23390; a selective D-2 antagonist, sulpiride; or a combination D-1/D-2 antagonist, cis-Z-flupenthixol, into the NA shell of postpartum female rats. Sulpiride-infused rats showed a significantly longer latency to exhibit full maternal behavior following a 10-day pup isolation period in comparison to the controls that received a vehicle. Cis-Z-flupenthixol disrupted maternal memory to a greater extent, as rats receiving this showed the longest latencies to express maternal behavior. SCH-23390 infusions had only marginal effects. These findings suggest that both the D-1 and the D-2 receptor subtypes play a role in the consolidation of maternal memory and they might do so by mediating the motivational salience of pup stimulation.
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