期刊
BEHAVIORAL NEUROSCIENCE
卷 122, 期 2, 页码 273-281出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.122.2.273
关键词
testosterone; finger-length ratio; 2D : 4D; ADHD; sex differences
资金
- NIMH NIH HHS [F31 MH075533, R21 MH 070542, T32 MH070343, T32 MH070343-01, R21 MH070542] Funding Source: Medline
- NINDS NIH HHS [R01 NS028421-17, R01 NS028421] Funding Source: Medline
Gonadal hormones may exert permanent organizational effects on sexually dimorphic finger-length ratios and sexually dimorphic behavior expressed in childhood attention deficit-hyperactivity disorder (ADHD). This study extended recent work examining associations between finger-length ratios (specifically, 213:41)) and ADHD in a well-characterized, clinically diagnosed, community-recruited sample of boys and girls. A multistage, diagnostic procedure was utilized to identify 113 children with ADHD and 137 non-ADHD comparison children. Right-hand digit ratios showed significant mean differences by gender, as well as associations with ADHD diagnosis. Boys with ADHD had more inasculinized digit ratios than control-group boys. More masculine right 2D:4D and 3D:4D ratios were correlated with parent- and teacher-rated inattentive and hyperactive-impulsive symptoms in boys but not in girls. Masculinized finger-length ratios were associated with hyperactive-impulsive and oppositional-defiant symptoms, but associations were largest with symptoms of inattention. It is concluded that prenatal, organizational effects of gonadal hormones may play a role in the development of ADHD and contribute to explaining sex differences in the prevalence rates of this childhood disorder.
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