期刊
CLINICAL AND EXPERIMENTAL MEDICINE
卷 1, 期 3, 页码 133-136出版社
SPRINGER-VERLAG
DOI: 10.1007/s10238-001-8024-1
关键词
interleukins; chemokine; valproate; carbamazepine; epilepsy
In order to evaluate whether treatment with valproic acid or carbamazepine can modify interleukins and monocyte chemoattractant protein-1, we studied 40 epileptic children and adolescents. We evaluated the patients before and after 1 year of therapy. At the end of follow-up, the patients showed a significant increase of the production of interleukin-1alpha, interleukin-1beta, interleukin-6, and monocyte chemoattractant protein-1; interleukin-2 production was significantly higher only in patients receiving carbamazepine. In conclusion, antiepileptic drugs can influence the immune system by modifying interleukin and chemokine concentrations; these changes seem to be independent of the serum concentrations of these drugs.
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