Background. The effectiveness of systematized hepatectomy with transection of Glisson's pedicle at the hepatic hilus in patients with small nodular hepatocellular carcinoma (HCC) has not been confirmed. Methods. Surgical outcomes were reviewed in 204 patients with single nodular HCCs less than 5 cm in greatest diameter, including 68 patients with tumors that showed extranodular growth and 136 patients with tumors that did not, who had undergone curative hepatectomy (Partial hepatic resection, n = 114; systematized hepatectomy, n = 90)from 1990 through 1994. Results. The rates of microscopic vascular invasion and intrahepatic metastasis were significantly higher in patients who had single nodular HCCs with extranodular growth (34 % and 49 %) than in Patients who had single nodular HCCs without extranodular growth (13 %, P = .001, and 4 %, P < .001). The 5-year survival rate in patients who had single nodular HCCs with extranodular growth was signiflicantly, greater after systematized hepatectomy (67 %) than after partial hepatic resection (21 %, P = .000). Multivariate analysis showed that the type of operation was an independent prognostic factor in patients with single nodular HCCs with extranodular growth (P = .0008). Conclusions. Systematized hepatectomy with Glisson's pedicle transection at the hepatic hilus should be performed in patients who have single small nodular HCCs with extranodular growth because these tumors often invade within the liver sector containing the tumor.
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