期刊
RESPIRATION PHYSIOLOGY
卷 127, 期 2-3, 页码 105-111出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S0034-5687(01)00244-4
关键词
cell, alveolar, stretch; disease, inflammation; enzymes, protein kinase C, alveolar cell; mammals, humans; mediators, growth factor, alveolar cell; mediators, interleukin-8; stretch, alveolar, growth factor
Positive-pressure mechanical ventilation can injure the lung, causing edema and alveolar inflammation in a complication termed ventilator-induced lung injury (VILI), Cytokines such as interleukin-8 (IL-8) reportedly are important in this inflammatory response. On the other hand. hepatocyte growth factor (HGF) promotes regeneration of the lung, and delays pulmonary fibrosis. We postulated that cyclic stretch upregulates production and release of both of mediators. Human alveolar epithelial cells (A549) cultured on a silicoelastic membrane were tested for mRNA expression and release of IL-8 and HGF after cyclic stretch in vitro. Stretch induced mRNA expression and release of these mediators. The signaling pathway from cyclic stretch to release of IL-8 and HGF appeared to involve protein kinase C in the signal transduction pathway. (C) 2001 Elsevier Science B.V. All rights reserved.
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