期刊
TETRAHEDRON
卷 57, 期 36, 页码 7771-7784出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4020(01)00744-X
关键词
tandem Michael/intramolecular aldol reaction; secondary amine; thiols; phosphines
The outcome of a tandem Michael/intramolecular aldol reaction which is mediated by secondary amines, thiols and phosphines has been found to be highly substrate dependent, with the best results being obtained for the formation of 5 and 6-membered rings using thiol or thiolate nucleophiles. Amine and phosphine mediated cyclisations were found to be problematic in several cases but were still effective methods for the formation of 5-7 membered rings. (C) 2001 Elsevier Science Ltd. All rights reserved.
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