期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 194, 期 5, 页码 669-676出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.194.5.669
关键词
autoimmunity; central nervous system; experimental autoimmune encephalomyelitis myelin basic protein; cytotoxic T cell
资金
- NCI NIH HHS [CA09537-13, T32 CA009537] Funding Source: Medline
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) characterized by plaques of infiltrating CD4(+) and CD8(+) T cells. Studies of MS and experimental autoimmune encephalomyelitis (EAE), an animal model of MS, focus on the contribution of CD4(+) myelin-specific T cells. The role of CD8(+) myelin-specific T cells in mediating EAE or MS has not been described previously. Here, we demonstrate that myelin-specific CD8(+) T cells induce severe CNS autoimmunity in mice. The pathology and clinical symptoms in CD8(+) T cell-mediated CNS autoimmunity demonstrate similarities to MS not seen in myelin-specific CD4(+) T cell-mediated EAE. These data suggest that myelin-specific CD8(+) T cells could function as effector cells in the pathogenesis of MS.
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