期刊
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 268, 期 1478, 页码 1855-1860出版社
ROYAL SOC
DOI: 10.1098/rspb.2001.1759
关键词
effective population size; genetic polymorphism; malaria; Plasmodium falciparum
资金
- NIGMS NIH HHS [GM34940] Funding Source: Medline
It has been proposed that the virulent human malaria parasite Plasmodium falciparum underwent a recent severe population bottleneck. In order to test this hypothesis, we estimated the effective population size of this species from the patterns of nucleotide substitution at 23 nuclear protein-coding loci, using a variety of methods based on coalescent theory. Both simple methods and phylogenetically based maximum likelihood methods yielded the conclusion that the effective population size of this species has been of the order of at least 105 for the past 300 000-400 000 years.
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