期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 286, 期 5, 页码 852-856出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1006/bbrc.2001.5484
关键词
AMP-activated protein kinase; AICAR (5-aminoimidazole-4-carboxamide; ribonucleoside); 3T3-L1 adipocytes; acetyl-CoA carboxylase; C/EBP (CAAT/enhancer binding protein); PPAR (peroxisome proliferator-activated; receptor)
资金
- NIDDK NIH HHS [DK35712] Funding Source: Medline
The AMP-activated protein kinase (AMPK) activator, 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), has been found to inhibit the differentiation of 3T3-L1 adipocytes, if added at an early phase of differentiation. AICAR blocks the expression of the late adipogenic markers, fatty acid synthase and acetyl-CoA carboxylase, and of the transcription factors, C/EBP alpha and PPAR gamma. It also inhibits early clonal expansion of pre-adipocytes, prevents the fall in C/EBP beta expression during the intermediate stage of differentiation and inhibits the late phase expression of CHOP-10, an antagonist of C/EBP beta. These data suggest a possible inhibitory role for AMPK in the process of adipose differentiation and suggest that AMPK might be a target to block adipogenesis. (C) 2001 Academic Press.
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