期刊
ONCOGENE
卷 20, 期 40, 页码 5595-5610出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1204595
关键词
c-myc; gene expression; lymphoma; apoptosis
资金
- NCI NIH HHS [CA51497, CA57431, CA69322] Funding Source: Medline
c-MYC is the prototype for oncogene activation by chromosomal translocation. In contrast to the tightly regulated expression of c-myc in normal cells, c-myc is frequently deregulated in human cancers. Herein, aspects of c-myc gene activation and the function of the c-Myc protein are reviewed. The c-myc gene produces an oncogenic transcription factor that affects diverse cellular processes involved in cell growth, cell proliferation, apoptosis and cellular metabolism. Complete removal of c-myc results in slowed cell growth and proliferation, suggesting that while c-myc is not required for cell proliferation, it acts as an integrator and accelerator of cellular metabolism and proliferation.
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