期刊
NEUROSCIENCE LETTERS
卷 310, 期 2-3, 页码 188-190出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/S0304-3940(01)02130-9
关键词
Alzheimer's disease; chromosome 12
Alzheimer's disease is a complex neurodegenerative disorder, characterized by cognitive decline and distinctive neuropathology. Using large extended families with multiple affected, we found that three markers on chromosome 12 were linked with late-onset Alzheimer's disease. These markers were downstream from the gene for alpha-2 macroglobulin. It is likely that multiple genes will be identified either as risk factors or as causative agents for late-onset Alzheimer's disease. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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