期刊
NEUROSCIENCE LETTERS
卷 310, 期 2-3, 页码 101-104出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(01)02060-2
关键词
glucose transporter; Glut1; Glut3; local cerebral transport rates; autoradiography; 3-O-methylglucose
The present study addresses the question whether local glucose transport kinetics are correlated with local glucose transporter densities in the brain. In 47 brain structures the local rate constants for 3- O-[C-14] methylglucose (3-O-MG) transport, K-1 and k(2), were quantified, and local glucose Glut1 and Glut3 transporter densities were determined by immuno-autoradiographic methods. Statistically significant correlations were found between the rate constants for glucose transport and the transporter densities. The correlations were tighter for Glut1 than for Glut3. Inasmuch as 3-O-MG is transported by the same transporter as glucose, these results indicate that the local densities of glucose transporters determine local glucose transport rates in the brain. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据