期刊
BIOCHEMICAL JOURNAL
卷 358, 期 -, 页码 657-664出版社
PORTLAND PRESS LTD
DOI: 10.1042/bj3580657
关键词
carbohydrate; intestine; Sd(a)/Cad antigen
资金
- NCI NIH HHS [CA 29321] Funding Source: Medline
This paper describes structural characterization, by NMR, MS and degradative studies of mucin glycans from normal human descending colon obtained freshly at autopsy. The saccharides were mainly based on core 3 (GlcNAc beta1-3GalNAc). Among the terminal saccharide determinants Sd(a)/Cad-antigen-like structures were prominent, and Lewis x, sialyl Lewis x and sulphated Lewis x were found as minor components, whereas blood group H and A antigenic determinants were absent. The saccharides were markedly different from those of mucins from colon cancers or colon cancer cell lines analysed so far, in which cores 1 and 2 are prominent features, and in which various other terminal determinants have been found, but not Sd(a)/Cad.
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