期刊
BRAIN RESEARCH
卷 913, 期 2, 页码 165-169出版社
ELSEVIER
DOI: 10.1016/S0006-8993(01)02780-9
关键词
circadian rhythm; complex partial seizure; thermoregulation; epilepsy; kindling
资金
- NINDS NIH HHS [K08-NS02021] Funding Source: Medline
Rationale: Epileptic seizures may alter neuroendocrinological cycles. Light pulses induce phase shifts in circadian rhythms. Using hippocampal-kindled rats to ensure maximal clinical expression, we determined if seizures likewise induce phase shifts. Methods: We monitored the circadian rhythm of temperature (CRT) with intraperitoneal radiotelemetry in rats (n = 21) isolated from time cues and light for 3-week trials. Seizures were triggered with hippocampal electrical stimulation at different circadian phases. Optimized, least-error phase shifts were calculated from preictal and postictal CRTs. Induced seizures were referenced to CRT (t(max)=00:00, 24-h circadian cycle). Results: Phase shifts (individual responses=57) differed across the circadian cycle. Rather than forming a clear phase-response curve, phase shifts were especially variable between 00:00 and 06:00 h. Conclusions: This study demonstrates that electrically-induced seizures induce advances and delays in CRT in a phase-dependent fashion but in a pattern different from typical light-induced phase shifts. Disorders of circadian regulation may contribute to some of the altered endogenous cycles associated with epilepsy. (C) 2001 Elsevier Science B.V. All rights reserved.
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