期刊
NEUROLOGY
卷 57, 期 6, 页码 1124-1126出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.57.6.1124
关键词
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资金
- NINDS NIH HHS [R0-1 NS36711-01] Funding Source: Medline
A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1 (214 cM, lod = 1.20), 9 (136 cM, lod = 1.30), 10 (88 cM, lod = 1.07), and 16 (114 cM, lod = 0.93). The chromosome 9 region overlaps the genes for dopamine P-hydroxylase and torsion dystonia. Although no strong evidence for linkage was found for any locus, these results may be of value in comparison with similar studies by others.
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