期刊
NEURON
卷 31, 期 6, 页码 1027-1034出版社
CELL PRESS
DOI: 10.1016/S0896-6273(01)00428-7
关键词
-
资金
- NIGMS NIH HHS [GM 08107] Funding Source: Medline
NMDA receptors (NMDARs) typically contribute to excitatory synaptic transmission in the CNS. While Ca2+ influx through NMDARs plays a critical role in synaptic plasticity, direct actions of NMDAR-mediated Ca2+ influx on neuronal excitability have not been well established. Here we show that Ca2+ influx through NMDARs is directly coupled to activation of BK-type Ca2+-activated K+ channels in outside-out membrane patches from rat olfactory bulb granule cells. Repetitive stimulation of glutamatergic synapses in olfactory bulb slices evokes a slow inhibitory postsynaptic current (IPSC) in granule cells that requires both NMDARs and BK channels. The slow IPSO is enhanced by glutamate uptake blockers, suggesting that extrasynaptic NMDARs underlie the response. These findings reveal a novel inhibitory action of extrasynaptic NMDARs in the brain.
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