期刊
CANCER LETTERS
卷 171, 期 1, 页码 87-101出版社
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3835(01)00631-0
关键词
B-myb; BS69; N-CoR; transformation; transcription; repression
类别
B-myb, a ubiquitously expressed member of the myb gene family, is highly regulated throughout the cell cycle and appears to be required for cell cycle progression. In contrast to its relatives A-myb, c-Myb, and v-myb, no transforming activity of B-myb has been reported thus far. We report here that B-myb can rescue senescence induced by an activated ras onco.-ene in rodent cells in vitro. We show that transformation by B-Myb involves its ability to activate transcription. Similar to other oncogenic transcription factors, such as c-Myc and E2F, we show that B-Myb also has repression activity. We demonstrate that the C-terminus of B-Myb can function as a repressor of transcription, that B-Myb interacts with the repressor molecules BS69 and N-CoR and that the repression function, like the transactivation domain, contributes to B-myb transformation. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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