期刊
SCIENCE
卷 293, 期 5539, 页码 2462-2465出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1062560
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资金
- NCI NIH HHS [CA50519, CA76260] Funding Source: Medline
- NIA NIH HHS [AG-917709] Funding Source: Medline
Telomeres are specialized nucleoprotein structures that stabilize the ends of linear eukaryotic chromosomes. In mammalian cells, abrogation of telomeric repeat binding factor TRF2 or DNA-dependent protein kinase (DNA-PK) activity causes end-to-end chromosomal fusion, thus establishing an essential role for these proteins in telomere function. Here we show that TRF2-mediated endcapping occurs after telomere replication. The postreplicative requirement for TRF2 and DNA-PKcs, the catalytic subunit of DNA-PK, is confined to only half of the telomeres, namely, those that were produced by leading-strand DNA synthesis. These results demonstrate a crucial difference in postrepticative processing of telomeres that is linked to their mode of replication.
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