期刊
MOLECULAR BRAIN RESEARCH
卷 93, 期 2, 页码 190-198出版社
ELSEVIER
DOI: 10.1016/S0169-328X(01)00197-8
关键词
neuronal death; kainic acid; p53; Bax; caspase-3; hippocampus
Apoptosis results from the activation of a programmed cellular cascade involving several mechanisms. In the present study, we have investigated the implication of three molecules of this cascade, p53, Bax and caspase-3, in neuronal death induced by kainic acid (KA) administration in mouse hippocampus. Using immunocytochemistry, western blot and quantification of enzyme activity, we observed in p53+/+ and p53-/- animals that KA induced neuronal death by both p53-dependent and independent pathways. Moreover, apoptosis (labeled by TUNEL) and the increase of bax and caspase-3 protein expression after the neurotoxic insult appeared to clearly depend on p53 expression. (C) 2001 Elsevier Science B V. All rights reserved.
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